Gold nanoparticles based sensors array in combination with pattern recognition method provide an effective diagnostic tool for lung cancer. This system can distinguish between the order prints of non-small cell lung cancer (NSCLC) and negative control with 100% accuracy. Among other advantages over conventional diagonistic method like GC-MS based systems, this is non-invasive, inexpensive scheme which do not need any preconcentrator and high expertise to use.
Scientists have designed an array of 18 chemiresistors based on functionalized Gold NPs for detecting headspace of NSCLC and the control medium. Each sensor is widely responsive to variety of odorants. Hence, each analyte yields a distinct signature from the array of broadly cross-reactive sensors.Sensors of Gold NPs mostly coated with hydrophobic functionalities that are almost insensitive to water and hence perticularly suitable for breath testing, since exhaled breath contains ~ 80% relative humidity. This journal article further establish that AuNPs sensors can also be used as highly sensitive, simple-to-use tool for understanding the biochemical background of endogenous compound appearing in exhaled breath.
For details, please refer to Small, 2009, 5, No. 22, 2618-2624
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