Almost all available hyperthermic techniques for cancer tumor therapy suffers with low spatial selectivity in the heating of tumors and surrounding healthy tissues.A new approach to overcome this limitation has been developed over last five years and it has been called 'plasmonic photothermal therapy(PPTT).
In this approach tumor tissues are labeled by gold(or silver) nanoparticle with different shapes and structures. By exposing nanoparticles to laser radiation near their plasmon-resonant absorption, it is possible to produce local heating of labeled cells without harming the healthy ones.
Recently, Scientists from Russia have used plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia.They have synthesized gold nanoshells with very high extinction in the NIR spectral range.Laser irradiation parameters are optimized on the basis of experiments conducted using test-tube phatom and laboratory rats.Thermal imaging system is used for studying temperature distribution on the animal skin surface athypodermic and intramuscular injection of gold nano-shells.
For more details refer to : Journal of Biomedical Optics 14(2), 021016
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